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To fight malaria, scientists have built a genetic system that forces an engineered trait into nearly all of an insect's offspring, instead of the usual half.

What is this self-spreading genetic technology called?

A gene drive
Gene drives bias inheritance so a trait, such as female infertility, sweeps through a population. CRISPR-based drives have crashed caged populations of malaria mosquitoes in laboratory trials.

A gene drive is the self-spreading genetic technology built to fight malaria, designed to bias inheritance so that an engineered trait, such as infertility in female mosquitoes, spreads through nearly all of a population's offspring instead of the usual fifty percent expected from normal genetics. Over successive generations, this bias can cause the trait to sweep rapidly through an entire wild population.

A vaccine works by training an individual's immune system to recognize and fight a specific pathogen, a completely different concept from altering how a trait spreads across generations. A microbiome refers to the community of microorganisms living in or on a host organism, not a genetic tool for forcing inheritance patterns.

CRISPR-based gene drives have successfully crashed caged populations of malaria-carrying mosquitoes in controlled laboratory trials, though releasing such a self-spreading technology into wild ecosystems remains a carefully debated step due to its potentially irreversible effects.

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