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In 2024, British researchers finally solved a puzzle that had confused blood specialists since 1972, after a pregnant patient's blood reacted oddly to nearly every donor sample available.

What did scientists confirm they had discovered?

A new human blood group system, called MAL
Researchers traced the mysterious AnWj antigen, first noticed in 1972, to the MAL gene, establishing MAL as the 47th recognized human blood group system. More than 99.9% of people carry this antigen, so identifying the rare AnWj-negative cases helps prevent dangerous transfusion reactions.

Scientists confirmed the discovery of a new human blood group system called MAL after tracing a mysterious antigen, first noticed in 1972, to its underlying gene. This antigen appears on the surface of red blood cells in more than 99.9 percent of people, so finding the small number of rare AnWj-negative individuals helps doctors avoid dangerous mismatches during blood transfusions.

A new jaw muscle or a new type of white blood cell would be unrelated discoveries in entirely different areas of anatomy and immunology, not connected to this decades-old transfusion mystery, which was specifically about a red blood cell surface marker.

It took over fifty years from the antigen's first observation in a confused blood sample to finally identifying its genetic cause, showing how some basic questions in medicine can remain unsolved for generations until the right combination of genetic tools and rare patient cases comes along.

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